Serum Amyloid A (SAA) / ADAMTS13 Panel (2-Plex)
Indications: Use this test for acute phase inflammatory detection, chronic inflammatory diseases
ANALYTES / BIOMARKERS
SAA, ADAMTS13
TURNAROUND-TIME (TAT)
1-5 Days
SAMPLE STABILITY
Samples collected for immune-related biomarkers are stable for approximately 1 year if kept frozen (-80˚C preferred). Samples that are left at room temperature beyond 30 minutes during sample collection or are stored at 4˚C are not stable and are not acceptable unless they are processed in BD P-100 tubes.
PROCEDURE / TECHNIQUE
Luminex® 100/200 (Addressable LASER Bead Immunoassay)
REFERENCE RANGE
Available for plasma-EDTA and CSF (SAA only). See example reports below.
CLINICAL ASSOCIATIONS
SAA is a key factor in the acute phase inflammatory response and its circulating levels rise dramatically (up to 1000-fold) in response to inflammatory stimuli. SAA has cytokine-like properties in inflammation, contributing to the regulation of immune cells and the induction of both pro-inflammatory and anti-inflammatory factors, indicating homeostatic roles for SAA in both the progression and resolution of inflammation. Although SAA is highly expressed in all inflammatory responses, it is a reliable biomarker for autoimmune and rheumatic diseases and is thought to contribute to the pathogenesis of rheumatoid arthritis, familial Mediterranean fever, sarcoidosis and vasculitis.
ADAMTS13 is a liver enzyme (metalloproteinase / zinc protease) that acts to cleave and degrade von Willebrand factor (VWF) (a protein that promotes platelet adhesion to sites of vascular damage). ADAMTS13 also acts as a carrier protein for blood-clotting factor VIII in blood circulation. Abnormalities in ADAMTS13 are associated with disordered clotting (coagulation).
See example reports below.
Example report – Abnormal plasma – AA amyloidosis
Example report – Abnormal plasma – Familial Mediterranean fever