Angiogenesis Panel (12-Plex)
Indications: Use this test to assess abnormalities of angiogenesis in cancer, autoimmune diseases, cardiovascular disease, or other chronic inflammatory conditions.
ANALYTES / BIOMARKERS
Angiopoietin-2, BMP-9, Endoglin, Endothelin-1, FGF-1, Follistatin, HB-EGF, HGF, Leptin, PLGF, VEGF-C, VEGF-D
TURNAROUND-TIME (TAT)
1-5 days
SAMPLE STABILITY
Samples collected for immune-related biomarkers are stable for approximately 1 year if kept frozen (-80˚C preferred). Samples that are left at room temperature beyond 30 minutes during sample collection or are stored at 4˚C are not stable and are not acceptable unless they are processed in BD P-100 tubes.
PROCEDURE / TECHNIQUE
Luminex® 100/200 (Addressable LASER Bead Immunoassay)
REFERENCE RANGE
Available for plasma-EDTA only
CLINICAL ASSOCIATIONS
Use this test to identify relevant therapy targets, determine disease mechanisms, and diagnose or monitor the following conditions associated with angiogenesis, vascular health, and tissue remodeling:
- Cancer: Evaluate tumor angiogenesis, progression, and response to therapy in various cancers, where biomarkers like Angiopoietin-2, VEGF-C, VEGF-D, HGF, and PLGF are involved in promoting new blood vessel formation and tumor growth.
- Cardiovascular Diseases: Assess cardiovascular conditions such as atherosclerosis, myocardial infarction, and heart failure. Biomarkers like Endothelin-1, BMP-9, Endoglin, and FGF-1 indicate vascular remodeling, endothelial dysfunction, and angiogenic activity.
- Chronic Wound Healing: Monitor chronic wound healing processes, including diabetic ulcers and venous leg ulcers. Biomarkers such as HB-EGF, FGF-1, and HGF are critical for tissue repair, cell proliferation, and angiogenesis.
- Pulmonary Diseases: Evaluate chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Biomarkers like VEGF-C, VEGF-D, and Follistatin indicate lung tissue remodeling and angiogenesis.
- Metabolic and Obesity-Related Disorders: Investigate metabolic syndrome, obesity, and related complications. Biomarkers such as Leptin and HGF are involved in metabolic regulation, inflammation, and angiogenesis.
- Peripheral Artery Disease (PAD): Assess the severity and progression of PAD, where biomarkers like Angiopoietin-2, Endothelin-1, and PLGF are indicative of angiogenic activity and vascular health.
- Neurological Disorders: Monitor neuroinflammatory and neurodegenerative conditions such as Alzheimer’s disease and multiple sclerosis, where biomarkers like VEGF-C and HB-EGF play roles in neuroprotection and angiogenesis.
The interpretation of these test results should be correlated with clinical findings and other diagnostic tests. Cytokine levels can vary due to many biological, physiological, and diurnal factors; their clinical significance must be assessed by a qualified healthcare professional. This information is not intended to be used as the sole basis for diagnosis or treatment decisions.