SAA/Cardiovascular Disease Panel (6-Plex)
Indications: Use this test to investigate the underlying molecular basis of suspected coagulopathies, cardiovascular disease, and acute or chronic inflammation
ANALYTES / BIOMARKERS
ADAMTS13, D-Dimer, SAA, sICAM-1, sP-Selectin, sVCAM-1
TURNAROUND-TIME (TAT)
1-5 days
SAMPLE STABILITY
Samples collected for immune-related biomarkers are stable for approximately 1 year if kept frozen (-80˚C preferred). Samples that are left at room temperature beyond 30 minutes during sample collection or are stored at 4˚C are not stable and are not acceptable unless they are processed in BD P-100 tubes.
PROCEDURE / TECHNIQUE
Luminex® 100/200 (Addressable LASER Bead Immunoassay)
REFERENCE RANGE
Available for plasma-EDTA only
CLINICAL ASSOCIATIONS
Use this test to identify relevant therapy targets, determine disease mechanisms, and diagnose or monitor the following conditions associated with vascular health, coagulation, and inflammation:
- Thrombotic Disorders: Assess conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE), and disseminated intravascular coagulation (DIC), where D-Dimer and ADAMTS13 levels can indicate abnormal clot formation and breakdown.
- Cardiovascular Diseases: Monitor cardiovascular conditions such as atherosclerosis, myocardial infarction, and stroke, where biomarkers like sICAM-1, sVCAM-1, and sP-Selectin indicate endothelial dysfunction and inflammation.
- Inflammatory Diseases: Evaluate chronic inflammatory conditions such as rheumatoid arthritis, inflammatory bowel disease (IBD), and systemic lupus erythematosus (SLE), where Serum Amyloid A (SAA) and soluble adhesion molecules (sICAM-1, sVCAM-1) can reflect the systemic inflammatory state.
- Sepsis and Critical Illness: Diagnose and monitor sepsis and related critical illnesses, where elevated levels of D-Dimer, SAA, and soluble adhesion molecules (sICAM-1, sVCAM-1, sP-Selectin) can indicate systemic inflammation, endothelial activation, and coagulopathy.
- Chronic Kidney Disease (CKD): Assess endothelial dysfunction and inflammation in CKD, where elevated levels of sICAM-1, sVCAM-1, and SAA are indicative of chronic inflammatory processes and vascular complications.
The interpretation of these test results should be correlated with clinical findings and other diagnostic tests. Cytokine levels can vary due to many biological, physiological, and diurnal factors; their clinical significance must be assessed by a qualified healthcare professional. This information is not intended to be used as the sole basis for diagnosis or treatment decisions.